The only thing so far that I've found is a pain in the ass is that it doesn't like to recover form fullscreen games...that's a tad annoying. Luckily, though, you can disable it and reenable it at any moment, so I just drop it when I go to a game like that, since I certainly don't care what my desktop looks like when I cannot see it.
*giggle*...OK, yes, I'm enjoying this entirely too much. Sue me.